Altering the Proclivity towards Daptomycin Resistance in Methicillin - Resistant 1 Staphylococcus aureus Using Combination with Other Antibiotics
نویسندگان
چکیده
3 Andrew D. Berti, Justine E. Wergin, Gary G. Girdaukas, Scott J. Hetzel, George Sakoulas, 4 Warren E. Rose 5 University of Wisconsin-Madison School of Pharmacy, Pharmacy Practice Division 6 University of Wisconsin-Madison School of Pharmacy, Analytical Instrumentation 7 Center 8 University of Wisconsin-Madison Department of Biostatistics and Medical Informatics 9 University of California San Diego, Department of Pediatrics 10
منابع مشابه
Altering the proclivity towards daptomycin resistance in methicillin-resistant Staphylococcus aureus using combinations with other antibiotics.
Daptomycin (DAP) is increasingly used as a part of combination therapy, particularly in complex methicillin-resistant Staphylococcus aureus (MRSA) infections. While multiple studies have reported the potential for synergy between DAP and adjunctive anti-infectives, few have examined the influence of adjunctive therapy on the emergence of DAP resistance. This study examined eight adjunctive anti...
متن کاملDaptomycin, fosfomycin, or both for treatment of methicillin-resistant Staphylococcus aureus osteomyelitis in an experimental rat model.
The in vivo activities of daptomycin, fosfomycin, and a combination of both antibiotics against a clinical isolate of methicillin-resistant Staphylococcus aureus (daptomycin MIC, 0.25 μg/ml; fosfomycin MIC, 0.5 μg/ml) were evaluated in a rat model of osteomyelitis. A total of 37 rats with experimental osteomyelitis were treated for 4 weeks with either 60 mg/kg of body weight of daptomycin subcu...
متن کاملEvaluating the Potentiating Effect of Galbanic acid from Ferula szowitsiana on three common antibiotics against resistant hospital isolates of Staphylococcus aureus
The plant kingdom constitutes a source of new chemical compounds, which may be important due to their potential uses in medicine, or their other biological properties. In this study, the effects of Galbanic acid (GA), a sesquiterpene coumarin from roots of Ferula szowitsiana, were investigated as a modulator of antibiotic resistance in clinical isolates of Staphylococcus aureus. Isolates of S. ...
متن کاملEvaluating the Potentiating Effect of Galbanic acid from Ferula szowitsiana on three common antibiotics against resistant hospital isolates of Staphylococcus aureus
The plant kingdom constitutes a source of new chemical compounds, which may be important due to their potential uses in medicine, or their other biological properties. In this study, the effects of Galbanic acid (GA), a sesquiterpene coumarin from roots of Ferula szowitsiana, were investigated as a modulator of antibiotic resistance in clinical isolates of Staphylococcus aureus. Isolates of S. ...
متن کاملPCR-mediated identification of Methicillin and Vancomycin resistant genes in Staphylococcus aureus strains isolated from the nasal cavity
Staphylococcus aureus is colonized in the human nasal cavity and would contaminate hospital and therapeutic environments. This bacterium has a genetic diversity in terms of resistance to antimicrobial agents. Therefore, the purpose of this study was identificatied of Methicillin and Vancomycin resistant genes in Staphylococcus aureus strains which has been isolated from the nasal cavity. 189 pa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2012